Endocrine Abstracts

Introduction: SFRP-4 is a recently described inflammatory cytokine influencing insulin secretion from human β cells as an extracellular modulator of Wingless (Wnt) pathway. The aim of this study is to compare serum SFRP-4 levels in patients with normal glucose tolerance (NGT), impaired glucose tolerance (IGT) and type 2 diabetes (T2DM), and to investigate its relation with other parameters.Methods: The study included 152 patients who applied to the ...

Introduction: Few studies have investigated the effect of gastric bypass surgery on lipid profile in obese patients with type 2 diabetes mellitus. We aimed to evaluate changes in lipid profile in obese diabetic patients undergoing Roux-en-Y gastric bypass (RYGB) surgery.Method: We retrospectively analysed 71 obese type 2 diabetic patients (46 women, 25 men) who underwent RYGB surgery. Weight, body mass index (BMI), total cholesterol (TC), high-density-li...

Aim: The aim of this study was to investigate the relationship between the clinical and laboratory findings of metabolic bone disease regarding the levels of osteoprotegerin (OPG) and the receptor activator of nuclear factor kappa B ligand (RANKL) in the patients with diabetic nephropathy.Material and method: This study includes 61 type 2 diabetic patients and age-, sex-matched 20 healthy subjects. Diabetic patients were divided into three groups accordi...

Introduction and Aim: In our study, the frequency of exocrine pancreatic insufficiency, and its relationship with the duration of diabetes and the level of glycemic control and other complications of diabetes were investigated in patients with diabetes mellitus.Materials and Methods: This paper was supported by Manisa Celal Bayar University Scientific Research Projects Coordination Unit, Project Number 2021-086. A total of 249 diabetic patients, 21 with ...

Introduction: Patients with Cushing’s Syndrome (CS) frequently have sleep complaints. The aim of the study was to evaluate the prevalance sleep disturbances and sleep structure of patients with CS.Materials and methods: 33 patients with CS were evaluated both clinically and with polysomnograhy (PSG) findings in terms of sleep disorders and data were compared with 20 healthy controls.Results: Seventeen (51.1%) patients with CS ...

Background: Acne, stria and decreased skin elasticity are dermatological features of Cushing’s syndrome (CS). Although it is known that collagen mass in skin is decreased in CS and glucocorticoids play a role in acneiform skin lesions, the dermatological findings of CS has not previously been measured by reliable methods.Objective: The aim of the present study was to measure skin elasticity, capacitance, sebum content, pH and temperature in CS befor...

Objective: The number of studies that investigate thyroid functions in obese patients is limited, and little known about the effect of co-existence of type 2 diabetes mellitus on thyroid functions. In our study, we aimed to evaluate the spectrum of thyroid function in the both diabetic and non-diabetic obese patients.Materials-Methods: 145 obese patients who were admitted to our department of endocrinology and metabolism, between June 2014 and December 2...

Background: Ectopic thyroid tissue (ETT) can be explained as the localisation of thyroid parenchyma outside the orthotopic position of the thyroid gland. It can be more easily found in the tongue, neck, mediastinum, great vessels, heart and anywhere along Wölfler area, but presentation in the adrenal glands is absolutely very rare.Case: A 39-year-old woman was referred to our Endocrinology outpatient clinic with an incidental adrenal mass which was ...

Aim: Vitamin D deficiency is reported as a risk factor for the development of diabetes in several epidemiologic studies. In this study, we investigated the frequency of 25-OH vitamin D deficiency in type 2 diabetes and the relationship between 25-OH vitamin D deficiency and microvascular complications.Materials and methods: Retrospectively, medical records of 557 type 2 diabetic patients admitted to the Endocrinology Outpatient Clinic in January–Mar...

Introduction: Diabetic nephropathy is the leading cause of chronic renal failure worldwide. Related to the increased glucose and its metabolites, activation of renin–angiotensin–aldosterone system, and increased oxidative stress are important in renal deterioration. The studies indicate that suppression of renin–angiotensin–aldosterone system slow down diabetic nephropathy; Nigella sativa decreases blood glucose and oxidative stress. Were viewed th...